Clayface is a name used by several DC Comics fictional characters, most of them possessing clay-like bodies and shapeshifting abilities. All of them have been enemies of Batman. Created by Bob Kane, the original Clayface, Basil Karlo, was a b movie actor who began a life of crime using the identity of a villain he portrayed in a horror film.

In the late 1950s, Batman began facing a series of science fiction-inspired foes and Matt Hagen, a treasure hunter given vast shapeshifting powers and resiliency by radioactive protoplasm, became the new Clayface. He retained the title for the next twenty-five years of comic book history. After Hagen’s death, Preston Payne became the third Clayface. A scientist suffering from hyperpituitarism, Payne used Hagen's blood to create a cure but became a clay-like creature that needed to pass his condition onto others to survive. His condition was used as a metaphor for drug abuse and sexually transmitted disease.